Bacterial Interactions with Aspergillus fumigatus in the Immunocompromised Lung

Osteomyelitis and lung abscess due to Aspergillus fumigatus in a chronic granulomatous disease patient

Background and Purpose: Chronic granulomatous disease (CGD) is an inherited disorder of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. This disorder results in recurrent life-threatening bacterial and fungal infections. Aspergillus species are the most common fungal infections in these patients. Case Report: Herein, we present a case of fungal infection in a girl wi...

Azole Resistance of Aspergillus fumigatus in Immunocompromised Patients with Invasive Aspergillosis

Author affiliations: Groupe Hospitalier Saint-Louis-LariboisièreFernand-Widal, Assistance Publique-Hôpitaux de Paris, Paris, France (A. Alanio, B. Denis, S. Hamane, E. Raffoux, R. Peffault de Latour, J. Menotti, S. Amorim, S. Touratier, A. Bergeron, S. Bretagne); Université Paris Diderot, Sorbonne Paris Cité, Paris (A. Alanio, R. Peffault de Latour, J. Menotti, S. Amorim, A. Bergeron, S. Bretag...

Azole Resistance of Aspergillus fumigatus in Immunocompromised Patients with Invasive Aspergillosis

malignancies. J Antimicrob Chemother. 2011;66:371–4. http://dx.doi.org/10.1093/jac/dkq450 4. De Pauw B, Walsh TJ, Donnelly JP, Stevens DA, Edwards JE, Calandra T, et al. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycos...

In Vitro Interactions between Antifungals and Immunosuppressants against Aspergillus fumigatus

Persistence versus Escape: Aspergillus terreus and Aspergillus fumigatus Employ Different Strategies during Interactions with Macrophages

Invasive bronchopulmonary aspergillosis (IBPA) is a life-threatening disease in immunocompromised patients. Although Aspergillus terreus is frequently found in the environment, A. fumigatus is by far the main cause of IBPA. However, once A. terreus establishes infection in the host, disease is as fatal as A. fumigatus infections. Thus, we hypothesized that the initial steps of disease establish...